The Potential of Herbal Plants and Bioactive β Sitosterol in Circumventing Alzheimer’s Disease – A Review

Alzheimer’s Disease (AD), a neurological ailment, mostly affects the older population all around world. Rational therapies show limited efficacy, adverse effects, and poor patient compliance therefore herbal drugs are considered as suitable supplementation to drug therapy for treatment of AD. According research, reduce symptoms AD also improve brain functioning by inhibition β amyloid, γ-secretase, acetylcholine along with regulation antioxidants activation α-secretase. Various plants like Salvia officinalis, Bertholletia excelsa, Withania somnifera Urtica dioica help in slowing down progression scavenging free radicals, inhibiting lipid peroxidation, tau phosphorylation. sitosterol, phytosterol found abundantly has ability cross Blood Brain Barrier thus acts bioactive constituent circumventing various disorders. Numerous vitro vivo investigations indicate that sitosterol shows immunomodulatory, lipid-lowering well antioxidant properties. The plant sterol, capacity decrease amyloid platelet synthesis, indicating it might be helpful prevention Treatment can lessen plaque burden enhance spatial learning recognition patients suffering from